LENVIMA® (lenvatinib) is used along with another medicine called everolimus to treat adults with a type of kidney cancer called advanced renal cell carcinoma (RCC) after one course of treatment with another anti-cancer medicine.
Differentiated thyroid 
Advanced kidney cancer (RCC) Advanced kidney cancer (RCC) 
Inoperable liver cancer (HCC)
Advanced endometrial cancer*
*Taken in combination with pembrolizumab.
†Taken in combination with everolimus after one course of treatment with another anti-cancer medicine.
Advanced kidney cancer (RCC)
How to take LENVIMA
LENVIMA is an oral medication, taken once a day at the same time, with or without food.
Your doctor will tell you how much LENVIMA to take and when to take it. Your doctor may choose to adjust your dose, stop treatment for some time, or completely stop treatment with LENVIMA if you have side effects.
Capsules not actual size.
The recommended dose for advanced kidney cancer is
18 mg LENVIMA and
5 mg everolimus, but your health care provider will tell you how much LENVIMA to take. This is not the standard everolimus dose when treating advanced kidney cancer alone.
Your health care provider may choose to adjust your dose, stop treatment for some time, or completely stop treatment with LENVIMA if you have side effects
If your dose changes, you may receive a new carton and you should begin taking your new dose as directed by your doctor.
Please consult the everolimus Prescribing Information or talk to your health care team to learn how to take everolimus.
Your health care provider will tell you how much LENVIMA to take and when to take it.
Your health care provider may also adjust your dose during treatment, stop treatment for some time, or completely stop treatment with LENVIMA if you have side effects.
This is just one example of a LENVIMA blister card. The card your doctor prescribed may look different than this one.
You should take LENVIMA every day without interruption, unless otherwise instructed by your health care provider. There are 6 cards in each carton, which adds up to a 30-day supply of LENVIMA.
Step 1:
Place your daily dose, up to 5 capsules, in a small container or oral syringe (approximately 20mL capacity).
Step 2:
Add 3 mL of water or apple juice to the container or oral syringe. Wait 10 minutes for the capsule shell (outer surface) to dissolve completely, then stir or shake the mixture for 3 minutes until capsules are fully dissolved. Do not break or crush the capsules.
Step 3:
Drink the liquid mixture or use an oral syringe to take directly into the mouth.
Step 4:
Next, using a second syringe, add an additional 2 mL of liquid to the other container or oral syringe (cap the first oral syringe before adding the additional water) then swirl or shake and take the liquid mixture. Repeat this step at least one time and until you cannot see any of the LENVIMA mixture left in the container or oral syringe to make sure all of the medicine is taken.
Note:
If 6 capsules are required for your daily dose, follow the above instructions using 3 capsules at a time.
Storage:
LENVIMA mixture may be stored in a covered container in the refrigerator at 36°F to 46°F (2°C to 8°C) for a maximum of 24 hours. Throw away the LENVIMA mixture if not used within 24 hours of mixing.
LENVIMA should be given in feeding tubes of at least 5 french diameter (polyvinyl chloride or polyurethane tube) and at least 6 French diameter (silicone tube).
Step 1:
Place your daily dose, up to 5 capsules, in a syringe (approximately 20 mL capacity).
Step 2:
Add 3 mL of water to the syringe. Wait 10 minutes for the capsule shell (outer surface) to dissolve completely, then stir or shake the mixture for 3 minutes until capsules are fully dissolved. Do not break or crush the capsules.
Step 3:
Give the mixture through a feeding tube.
Step 4:
Next, cap the syringe and remove the plunger. Use a second syringe and add an additional 2mL of liquid to the syringe. Swirl or shake and give the mixture in the feeding tube. Repeat this step at least one time and until you cannot see any of the LENVIMA mixture left in the syringe to make sure all of the medicine is taken.
Note:
If 6 capsules are required for your daily dose, follow the above instructions using 3 capsules at a time.
Storage:
LENVIMA mixture may be stored in a covered container in the refrigerator at 36°F to 46°F (2°C to 8°C) for a maximum of 24 hours. Throw away the LENVIMA mixture if not used within 24 hours of mixing.
Call your health care provider or go to the nearest hospital
emergency room right away.
Be sure to store LENVIMA in a room with steady temperature.
Do not use LENVIMA for a condition for which it was not prescribed. Do not give LENVIMA to other people, even if they have the same symptoms you have. It may harm them. You can ask your health care provider or pharmacist for information about LENVIMA that is written for health care professionals.
Find information about how LENVIMA may work, how it is taken, tips for managing treatment, and more.
Financial assistance programs are
available to help appropriate
patients access LENVIMA.
